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Neurobiology

All change at the synapse

Two groups, using different approaches, have provided the first quantitative evidence that neurotransmitter release in the brain often occurs by a long-sought 'kiss-and-run' process.

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Figure 1: Visualizing vesicles.

References

  1. Katz, B. The Release of Neural Transmitter Substances (Liverpool Univ. Press., 1969).

  2. Heuser, J. E. & Reese, T. S. J. Cell Biol. 57, 315–344 (1973).

    Article  CAS  Google Scholar 

  3. Ceccarelli, B. & Hurlbut, W. P. Physiol. Rev. 60, 396–441 (1980).

    Article  CAS  Google Scholar 

  4. Alvarez de Toledo, G., Fernandez-Chacon, R. & Fernandez, J. M. Nature 363, 554–558 (1993).

    Article  ADS  Google Scholar 

  5. Gandhi, S. P. & Stevens, C. F. Nature 423, 607–613 (2003).

    Article  ADS  CAS  Google Scholar 

  6. Aravanis, A. M., Pyle, J. L. & Tsien, R. W. Nature 423, 643–647 (2003).

    Article  ADS  CAS  Google Scholar 

  7. Miesenbock, G., De Angelis, D. A. & Rothman, J. E. Nature 394, 192–195 (1998).

    Article  ADS  CAS  Google Scholar 

  8. Cochilla, A. J., Angleson, J. K. & Betz, W. J. Annu. Rev. Neurosci. 22, 1–10 (1999).

    Article  CAS  Google Scholar 

  9. Murthy, V. N. & Stevens, C. F. Nature 392, 497–501 (1998).

    Article  ADS  CAS  Google Scholar 

  10. Zenisek, D., Steyer, J. A. & Almers, W. Nature 406, 849–854 (2000).

    Article  ADS  CAS  Google Scholar 

  11. Zenisek, D., Steyer, J. A., Feldman, M. E. & Almers, W. Neuron 35, 1085–1097 (2002).

    Article  CAS  Google Scholar 

  12. Harata, N. et al. Trends Neurosci. 24, 637–643 (2001).

    Article  CAS  Google Scholar 

  13. Heuser, J. Science 300, 1248 (2003).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to William J. Betz.

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Rizzoli, S., Betz, W. All change at the synapse. Nature 423, 591–592 (2003). https://doi.org/10.1038/423591a

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