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Gene expression

Silent clones speak up

An important category of genes — so-called pluripotency genes — are active in early embryos but silent in specialized cells. It seems that this silencing is difficult to reverse in cloned embryos.

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Figure 1: Why is cloning inefficient?

References

  1. Boiani, M., Eckardt, S., Schöler, H. R. & McLaughlin, K. J. Genes Dev. 16, 1209–1219 (2002).

    Article  CAS  Google Scholar 

  2. Bortvin, A. et al. Development 130, 1673–1680 (2003).

    Article  CAS  Google Scholar 

  3. Wilmut, I. et al. Nature 419, 583–587 (2002).

    Article  ADS  CAS  Google Scholar 

  4. Smith, A. G. Annu. Rev. Cell. Dev. Biol. 17, 435–462 (2001).

    Article  CAS  Google Scholar 

  5. Gao, S. et al. Biol. Reprod. doi:10.1095/biolreprod.102.014522 (2003).

  6. Humpherys, D. et al. Proc. Natl Acad. Sci. USA 99, 12889–12894 (2002).

    Article  ADS  CAS  Google Scholar 

  7. Inoue, K. et al. Science 295, 297 (2002).

    Article  CAS  Google Scholar 

  8. Byrne, J. A., Simonsson, S. & Gurdon, J. B. Proc. Natl Acad. Sci. USA 99, 6059–6063 (2002).

    Article  ADS  CAS  Google Scholar 

  9. Santos, F., Hendrich, B., Reik, W. & Dean, W. Dev. Biol. 241, 172–182 (2002).

    Article  CAS  Google Scholar 

  10. Santos, F. et al. Curr. Biol. (in the press).

  11. Bird, A. Nature Immunol. 4, 208–209 (2003).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Wolf Reik.

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Reik, W., Dean, W. Silent clones speak up. Nature 423, 390–391 (2003). https://doi.org/10.1038/423390a

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