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Computational biology

Biosensor design

A series of bacterial receptor proteins have been 'redesigned' by computer so that they bind molecules that are quite different from their natural ligands. The approach might be useful for designing catalytic proteins.

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Figure 1: Computational design of binding proteins.


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Correspondence to William F. DeGrado.

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DeGrado, W. Biosensor design. Nature 423, 132–133 (2003).

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