Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Computational biology

Biosensor design

Nature volume 423, pages 132–133 (2003)Cite this article

A series of bacterial receptor proteins have been 'redesigned' by computer so that they bind molecules that are quite different from their natural ligands. The approach might be useful for designing catalytic proteins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Computational design of binding proteins.

References

  1. Looger, L. L., Dwyer, M. A., Smith, J. J. & Hellinga, H. W. Nature 423, 185–190 (2003).

    Article  ADS  CAS  Google Scholar 

  2. Hoess, R. Chem. Rev. 101, 3205–3218 (2001).

    Article  CAS  Google Scholar 

  3. Dower, W. J. & Mattheakis, L. C. Curr. Opin. Biotechnol. 6, 390–398 (2002).

    Article  CAS  Google Scholar 

  4. Tam, R. & Saier, M. H. Jr Microbiol. Rev. 57, 320–346 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Desjarlais, J. R. & Clarke, N. D. Curr. Opin. Struct. Biol. 8, 471–475 (1998).

    Article  CAS  Google Scholar 

  6. Lasters, I., De Maeyer, M. & Desmet, J. Protein Eng. 8, 815–822 (1995).

    Article  CAS  Google Scholar 

  7. Dahiyat, B. I. & Mayo, S. L. Science 278, 82–87 (1997).

    Article  CAS  Google Scholar 

  8. Ghirlanda, G., Lear, J. D., Lombardi, A. & DeGrado, W. F. J. Mol. Biol. 281, 379–391 (1998).

    Article  CAS  Google Scholar 

  9. Reina, J. et al. Nature Struct. Biol. 9, 621–627 (2002).

    CAS  PubMed  Google Scholar 

  10. Wentworth, P. Jr & Janda, K. D. Cell Biochem. Biophys. 35, 63–87 (2001).

    Article  CAS  Google Scholar 

  11. Bolon, D. N. & Mayo, S. Proc. Natl Acad. Sci. USA 98, 14272–14279 (2001).

    Article  ADS  Google Scholar 

  12. Baltzer, L. & Nilsson, J. Curr. Opin. Biotechnol. 12, 355–360 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, 19104-6059, Pennsylvania, USA

    William F. DeGrado

Authors
  1. William F. DeGrado
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to William F. DeGrado.

Rights and permissions

Reprints and permissions

About this article

Cite this article

DeGrado, W. Biosensor design. Nature 423, 132–133 (2003). https://doi.org/10.1038/423132a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/423132a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing