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Molecular biology

Complicity of gene and pseudogene

'Pseudogenes' are produced from functional genes during evolution, and are thought to be simply molecular fossils. The unexpected discovery of a biological function for one pseudogene challenges that popular belief.

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Figure 1: Gene regulation by a pseudogene.


  1. Harrison, P. M. et al. Genome Res. 12, 272–280 (2002).

    CAS  Article  Google Scholar 

  2. International Human Genome Sequencing Consortium Nature 409, 860–921 (2001).

  3. Mouse Genome Sequencing Consortium Nature 420, 520–562 (2002).

  4. Harrison, P. M. & Gerstein, M. J. Mol. Biol. 318, 1155–1174 (2002).

    CAS  Article  Google Scholar 

  5. Hirotsune, S. et al. Nature 423, 91–96 (2003).

    CAS  Article  ADS  Google Scholar 

  6. Gray, T. A. et al. Genomics 66, 76–86 (2000).

    CAS  Article  Google Scholar 

  7. Eddy, S. R. Nature Rev. Genet. 2, 919–929 (2001).

    CAS  Article  Google Scholar 

  8. Mignone, F., Gissi, C., Liuni, S. & Pesole, G. Genome Biol. 3, 4.1–4.10 (2002).

    Article  Google Scholar 

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Correspondence to Jeannie T. Lee.

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Lee, J. Complicity of gene and pseudogene. Nature 423, 26–28 (2003).

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