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Structural biology

Life's transistors

Voltage-gated ion channels control electrical activity in nerve, muscle and many other cell types. The crystal structure of a bacterial voltage-gated channel reveals the astonishingly simple design of its voltage sensor.

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Figure 1: Voltage sensing in a potassium ion channel.

References

  1. Hodgkin, A. L. & Huxley, A. F. J. Physiol. (Lond.) 117, 500–544 (1952).

    Article  CAS  Google Scholar 

  2. Jiang, Y. et al. Nature 423, 33–41 (2003).

    Article  CAS  ADS  Google Scholar 

  3. Jiang, Y. et al. Nature 423, 42–48 (2003).

    Article  CAS  ADS  Google Scholar 

  4. Bezanilla, F. Physiol. Rev. 80, 555–592 (2002).

    Article  Google Scholar 

  5. del Camino, D. & Yellen, G. Neuron 32, 649–656 (2002).

    Article  Google Scholar 

  6. Noda, M. et al. Nature 312, 121–127 (1984).

    Article  CAS  ADS  Google Scholar 

  7. Gandhi, C. S. & Isacoff, E. Y. J. Gen. Physiol. 120, 455–463 (2002).

    Article  CAS  Google Scholar 

  8. Ruta, V. et al. Nature 422, 180–185 (2003).

    Article  CAS  ADS  Google Scholar 

  9. Yang, N., George, A. L. & Horn, R. Neuron 16, 113–122 (1996).

    Article  Google Scholar 

Download references

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Correspondence to Fred J. Sigworth.

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Sigworth, F. Life's transistors. Nature 423, 21–22 (2003). https://doi.org/10.1038/423021a

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  • DOI: https://doi.org/10.1038/423021a

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