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Cancer

Escape from inhibition

Mutations in the Abl protein cause some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.

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Figure 1: The domain structure of the enzymes Abl and Src.
Figure 2: The regulation of Src and Abl.

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Correspondence to Sara A. Courtneidge.

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Courtneidge, S. Escape from inhibition. Nature 422, 827–828 (2003). https://doi.org/10.1038/422827a

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