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Cancer

Escape from inhibition

Nature volume 422, pages 827–828 (2003)Cite this article

Mutations in the Abl protein cause some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.

The enigmatic protein Abl has just given up another of its secrets. This enzyme is important because in mutated, activated form it causes some types of human leukaemia — so researchers have been keen to learn how it is regulated. That goal became still more precious when it was realized that the resistance of leukaemia to Gleevec (a drug that inhibits Abl) often results from further mutations in Abl itself. But until now the protein has stubbornly resisted attempts to understand it.

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Figure 1: The domain structure of the enzymes Abl and Src.
Figure 2: The regulation of Src and Abl.

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  1. Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, Michigan, 49503, USA

    Sara A. Courtneidge

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  1. Sara A. Courtneidge
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Correspondence to Sara A. Courtneidge.

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Courtneidge, S. Escape from inhibition. Nature 422, 827–828 (2003). https://doi.org/10.1038/422827a

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