Mutations in the Abl protein cause some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.
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Hantschel, O. et al. Cell 112, 845–857 (2003).
Nagar, B. et al. Cell 112, 859–871 (2003).
Azam, M., Latek, R. R. & Daley, G. Q. Cell 112, 831–843 (2003).
Superti-Furga, G. & Courtneidge, S. BioEssays 17, 321–330 (1995).
Smith, J. M. & Mayer, B. J. Front. Biosci. 7, d31–d42 (2002).
Mauro, M. J. & Druker, B. J. Curr. Opin. Oncol. 13, 3–7 (2001).
Nagar, B. et al. Cancer Res. 62, 4236–4243 (2002).
Schindler, T. et al. Science 289, 1938–1942 (2000).
McCormick, F. Nature 412, 281–282 (2001).
Mayer, B. J. Curr. Biol. 7, R295–R298 (1997).
Pluk, H., Dorey, K. & Superti-Furga, G. Cell 108, 247–259 (2002).
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Courtneidge, S. Escape from inhibition. Nature 422, 827–828 (2003). https://doi.org/10.1038/422827a
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