It remains uncertain how tissue-specific stem cells could generate the mature cell types of another tissue. In one instance, where bone-marrow-derived stem cells repair damaged liver in mice, cell fusion is the answer.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Wang, X. et al. Nature 422, 897–901 (2003).
Vassilopoulos, G., Wang, P.-R & Russell, D. W. Nature 422, 901–904 (2003).
Blau, H. M., Brazelton, T. R. & Weimann, J. M. Cell 105, 829–841 (2001).
Anderson, D. J., Gage, F. H. & Weissman, I. L. Nature Med. 7, 393–395 (2001).
Lagasse, E. et al. Nature Med. 6, 1229–1234 (2000).
Ephrussi, B. Hybridization of Somatic Cells (Princeton Univ. Press, 1972).
Terada, N. et al. Nature 416, 542–545 (2002).
Ying, Q. L., Nichols, J., Evans, E. P. & Smith, A. G. Nature 416, 545–548 (2002).
Wagers, A. J., Sherwood, R. I., Christensen, J. L. & Weissman, I. L. Science 297, 2256–2259 (2002).
Jiang, Y. et al. Nature 418, 41–49 (2002).
Rights and permissions
About this article
Cite this article
Medvinsky, A., Smith, A. Fusion brings down barriers. Nature 422, 823–825 (2003). https://doi.org/10.1038/422823a
This article is cited by
Growth factors enhance liver regeneration in acute-on-chronic liver failure
Hepatology International (2014)
Bone marrow-derived cells contribute to NDEA-induced lung squamous cell carcinoma
Tumor Biology (2013)
Strategies for achieving and monitoring myelin repair
Journal of Neurology (2007)