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Oxygen and the inflammatory cell

The discovery that a single protein allows certain immune cells both to respond to low oxygen levels and to induce inflammation may provide a new target for drugs to treat diseases characterized by excessive inflammation.

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Figure 1: Factors that may control, or be controlled by, hypoxia-inducible factor-1α (HIF-1α) in inflammatory sites with low oxygen levels.


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Correspondence to Carl Nathan.

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Nathan, C. Oxygen and the inflammatory cell. Nature 422, 675–676 (2003).

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