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Immunology

Oxygen and the inflammatory cell

Nature volume 422, pages 675–676 (2003)Cite this article

The discovery that a single protein allows certain immune cells both to respond to low oxygen levels and to induce inflammation may provide a new target for drugs to treat diseases characterized by excessive inflammation.

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Figure 1: Factors that may control, or be controlled by, hypoxia-inducible factor-1α (HIF-1α) in inflammatory sites with low oxygen levels.

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  1. the Department of Microbiology and Immunology and Graduate Programs in Immunology and Molecular Biology, Weill Medical College, Cornell University, 1300 York Avenue, New York, 10021, New York, USA

    Carl Nathan

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  1. Carl Nathan
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Correspondence to Carl Nathan.

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Nathan, C. Oxygen and the inflammatory cell. Nature 422, 675–676 (2003). https://doi.org/10.1038/422675a

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