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Ballads of a protein quartet

The fate of neurons in the developing brain and in Alzheimer's disease may lie with a four-protein complex that regulates the cleavage of two molecules spanning the cell membrane. The role of each protein is now being unveiled.

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Figure 1: The γ-secretase protein quartet, and its roles in brain development and Alzheimer's disease.


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Correspondence to Mark P. Mattson.

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Mattson, M. Ballads of a protein quartet. Nature 422, 385–387 (2003).

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