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Molecular motors

A magnificent machine

Electron-microscope studies of the motor protein dynein reveal fascinating details of the movements of its various structural regions. The protein displays a degree of gymnastic ability that is rarely seen.

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Figure 1: Understanding dynein.


  1. Burgess, S. A., Walker, M. L., Sakakibara, H., Knight, P. J. & Oiwa, K. Nature 421, 715–718 (2003).

    Article  ADS  CAS  Google Scholar 

  2. Vale, R. D. & Fletterick, R. J. Annu. Rev. Cell. Dev. Biol. 13, 745–777 (1997).

    Article  CAS  Google Scholar 

  3. Neuwald, A. F., Aravind, L., Spouge, J. L. & Koonin, E. V. Genome Res. 9, 27–43 (1999).

    CAS  PubMed  Google Scholar 

  4. Mocz, G. & Gibbons, I. R. Structure 9, 93–103 (2001).

    Article  CAS  Google Scholar 

  5. Ogura, T. & Wilkinson, A. J. Genes Cells 6, 575–597 (2001).

    Article  CAS  Google Scholar 

  6. Samso, M., Radermacher, M., Frank, J. & Koonce, M. P. J. Mol. Biol. 276, 927–937 (1998).

    Article  CAS  Google Scholar 

  7. Gee, M. A., Heuser, J. E. & Vallee, R. B. Nature 390, 636–639 (1997).

    Article  ADS  CAS  Google Scholar 

  8. Goodenough, U. W. & Heuser, J. E. J. Mol. Biol. 180, 1083–1118 (1984).

    Article  CAS  Google Scholar 

  9. Holzbaur, E. L. & Johnson, K. A. Biochemistry 28, 5577–5585 (1989).

    Article  CAS  Google Scholar 

  10. Yu, R. C., Hanson, P. I., Jahn, R. & Brunger, A. T. Nature Struct. Biol. 5, 803–811 (1998).

    Article  CAS  Google Scholar 

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Correspondence to Richard B. Vallee.

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Vallee, R., Höök, P. A magnificent machine. Nature 421, 701–702 (2003).

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