Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Molecular motors

A magnificent machine

Electron-microscope studies of the motor protein dynein reveal fascinating details of the movements of its various structural regions. The protein displays a degree of gymnastic ability that is rarely seen.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Understanding dynein.

References

  1. Burgess, S. A., Walker, M. L., Sakakibara, H., Knight, P. J. & Oiwa, K. Nature 421, 715–718 (2003).

    ADS  CAS  Article  Google Scholar 

  2. Vale, R. D. & Fletterick, R. J. Annu. Rev. Cell. Dev. Biol. 13, 745–777 (1997).

    CAS  Article  Google Scholar 

  3. Neuwald, A. F., Aravind, L., Spouge, J. L. & Koonin, E. V. Genome Res. 9, 27–43 (1999).

    CAS  PubMed  Google Scholar 

  4. Mocz, G. & Gibbons, I. R. Structure 9, 93–103 (2001).

    CAS  Article  Google Scholar 

  5. Ogura, T. & Wilkinson, A. J. Genes Cells 6, 575–597 (2001).

    CAS  Article  Google Scholar 

  6. Samso, M., Radermacher, M., Frank, J. & Koonce, M. P. J. Mol. Biol. 276, 927–937 (1998).

    CAS  Article  Google Scholar 

  7. Gee, M. A., Heuser, J. E. & Vallee, R. B. Nature 390, 636–639 (1997).

    ADS  CAS  Article  Google Scholar 

  8. Goodenough, U. W. & Heuser, J. E. J. Mol. Biol. 180, 1083–1118 (1984).

    CAS  Article  Google Scholar 

  9. Holzbaur, E. L. & Johnson, K. A. Biochemistry 28, 5577–5585 (1989).

    CAS  Article  Google Scholar 

  10. Yu, R. C., Hanson, P. I., Jahn, R. & Brunger, A. T. Nature Struct. Biol. 5, 803–811 (1998).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard B. Vallee.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Vallee, R., Höök, P. A magnificent machine. Nature 421, 701–702 (2003). https://doi.org/10.1038/421701a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/421701a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing