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Human genetics

Lost anchors cost lives

Mutations in ion-transport proteins can destabilize the electrical activity of the heart, causing sudden death. It now seems that mutations in a protein that anchors ion transporters to cell membranes can have the same effect.

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Figure 1: The electrical activity underlying heart beats, and the role of the ankyrin-B protein.


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Correspondence to Stanley Nattel.

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Nattel, S. Lost anchors cost lives. Nature 421, 587–589 (2003).

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