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A nervous connection

The molecular details of a connection between the nervous system and the inflammatory response to disease have been uncovered. This suggests new avenues of research into controlling excessive inflammation.

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Figure 1: The inflammatory response to microorganisms, and ways of controlling it.


  1. Stone, R. Science 64, 365–367 (1994).

    Article  ADS  Google Scholar 

  2. Wang, H. et al. Nature 421, 384–388 (2003); advance online publication, 22 December 2002 (doi: 10.1038/nature01339).

    Article  ADS  CAS  Google Scholar 

  3. Vassalli, P. Annu. Rev. Immunol. 10, 411–452 (1992).

    Article  CAS  Google Scholar 

  4. Wielockx, B. et al. Nature Med. 7, 1202–1208 (2001).

    Article  CAS  Google Scholar 

  5. Feldmann, M. Nature Rev. Immunol. 2, 364–371 (2002).

    Article  CAS  Google Scholar 

  6. Tracey, K. J. et al. Science 234, 470–474 (1986).

    Article  ADS  CAS  Google Scholar 

  7. Borovikova, L. V. Nature 405, 458–462 (2000).

    Article  ADS  CAS  Google Scholar 

  8. Bernik, T. R. et al. J. Exp. Med. 195, 781–788 (2002).

    Article  CAS  Google Scholar 

  9. Sopori, M. Nature Rev. Immunol. 2, 372–377 (2002).

    Article  CAS  Google Scholar 

  10. Talley, N. J. & Spiller, R. Lancet 360, 555–564 (2002).

    Article  Google Scholar 

  11. Son, Y. S. et al. Neurosci. Lett. 319, 45–48 (2002).

    Article  CAS  Google Scholar 

  12. King, D. E., Mainous, A. G. III, Steyer, T. E. & Pearson, W. Int. J. Psychiatry Med. 31, 415–425 (2001).

    Article  CAS  Google Scholar 

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Correspondence to Claude Libert.

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Libert, C. A nervous connection. Nature 421, 328–329 (2003).

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