Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Fear thou not

Mice lacking a certain neurotransmitter receptor have trouble forgetting scary experiences. This finding uncovers a fear-regulating feedback loop in the brain that might be at work in humans, too.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Neuronal circuits and frightened mice.


  1. LeDoux, J. E. The Emotional Brain: The Mysterious Underpinning of Emotional Life (Simon & Schuster, New York, 1996).

    Google Scholar 

  2. Shumyatsky, G. P. et al. Cell 111, 905–918 (2002).

    Article  CAS  Google Scholar 

  3. Aggleton, J. P. (ed.) The Amygdala: A Functional Analysis (Oxford Univ. Press, Oxford, 2000).

    Google Scholar 

  4. Cahill, L., Weinberger, N. M., Roozendaal, B. & McGaugh, J. L. Neuron 23, 227–228 (1999).

    Article  CAS  Google Scholar 

  5. Maren, S., Aharonov, G., Stote, D. L. & Fanselow, M. S. Behav. Neurosci. 110, 1365–1374 (1996).

    Article  CAS  Google Scholar 

  6. Lamprecht, R., Farb, C. R. & LeDoux, J. E. Neuron 36, 727–738 (2002).

    Article  CAS  Google Scholar 

  7. Ressler, K. J., Paschall, G., Zhou, X. L. & Davis, M. J. Neurosci. 22, 7892–7902 (2002).

    Article  CAS  Google Scholar 

  8. Rogan, M. T., Staubli, U. V. & LeDoux, J. E. Nature 390, 604–607 (1997).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Yadin Dudai.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dudai, Y. Fear thou not. Nature 421, 325–327 (2003).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing