One way of finding out what genes do is to inactivate them, and to study the effects, in 'model' organisms. That has now been done for many thousands of worm genes in two large-scale analyses.
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References
Kamath, R. S. et al. Nature 421, 231–237 (2003).
Ashrafi, K. et al. Nature 421, 268–272 (2003).
Fire, A. et al. Nature 391, 806–811 (1998).
Plasterk, R. H. Science 296, 1263–1265 (2002).
Timmons, L. & Fire, A. Nature 395, 854 (1998).
Fraser, A. G. et al. Nature 408, 325–330 (2000).
Gönczy, P. et al. Nature 408, 331–336 (2000).
Maeda, I., Kohara, Y., Yamamoto, M. & Sugimoto, A. Curr. Biol. 11, 171–176 (2001).
McManus, M. T. & Sharp, P. A. Nature Rev. Genet. 3, 737–747 (2002).
Tuschl, T. Nature Biotechnol. 20, 446–448 (2002).
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Tuschl, T. RNA sets the standard. Nature 421, 220–221 (2003). https://doi.org/10.1038/421220a
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DOI: https://doi.org/10.1038/421220a
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