Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Circadian rhythms

The cancer connection

The Per2 gene is a core component of the circadian clock in mammals. It now seems that the mouse Per2 gene is also involved in suppressing tumours, through other genes that affect cell proliferation and death.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Fu, L., Pelicano, H., Liu, J., Huang, P. & Lee, C. C. Cell 111, 41–50 (2002).

    Article  CAS  Google Scholar 

  2. Zheng, B. H. et al. Nature 400, 169–173 (1999).

    Article  ADS  CAS  Google Scholar 

  3. Konopka, R. J. & Benzer, S. Proc. Natl Acad. Sci. USA 68, 2112–2116 (1971).

    Article  ADS  CAS  Google Scholar 

  4. Allada, R., Emery, P., Takahashi, J. S. & Rosbash, M. Annu. Rev. Neurosci. 24, 1091–1119 (2001).

    Article  CAS  Google Scholar 

  5. Zheng, B. H. et al. Cell 105, 683–694 (2001).

    Article  CAS  Google Scholar 

  6. Akhtar, R. A. et al. Curr. Biol. 12, 540–550 (2002).

    Article  CAS  Google Scholar 

  7. Panda, S. et al. Cell 109, 307–320 (2002).

    Article  CAS  Google Scholar 

  8. Storch, K. F. et al. Nature 417, 78–83 (2002).

    Article  ADS  CAS  Google Scholar 

  9. Ueda, H. R. et al. Nature 418, 534–539 (2002).

    Article  ADS  CAS  Google Scholar 

  10. Balsalobre, A., Damiola, F. & Schibler, U. Cell 93, 929–937 (1998).

    Article  CAS  Google Scholar 

  11. Johnson, C. H. & Golden, S. S. Annu. Rev. Microbiol. 53, 389–409 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rosbash, M., Takahashi, J. The cancer connection. Nature 420, 373–374 (2002). https://doi.org/10.1038/420373a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/420373a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing