Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Pinning a change on p53

An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Regulation of p53 protein by Pin1, as suggested by the results of Zheng et al.1 and Zacchi et al.2.


  1. Zheng, H. et al. Nature 419, 849–853 (2002); advance online publication, 2 October 2002 (doi:10.1038/nature01116).

    Article  CAS  ADS  Google Scholar 

  2. Zacchi, P. et al. Nature 419, 853–857 (2002); advance online publication, 2 October 2002 (doi:10.1038/nature01120).

    Article  CAS  ADS  Google Scholar 

  3. Ryan, K. M., Phillips, A. C. & Vousden, K. H. Curr. Opin. Cell Biol. 13, 332–337 (2001).

    Article  CAS  Google Scholar 

  4. Vousden, K. H. & Lu, X. Nature Rev. Cancer 2, 594–604 (2002).

    Article  CAS  Google Scholar 

  5. Kubbutat, M. H., Jones, S. N. & Vousden, K. H. Nature 387, 299–303 (1997).

    Article  CAS  ADS  Google Scholar 

  6. Haupt, Y., Maya, R., Kazaz, A. & Oren, M. Nature 387, 296–299 (1997).

    Article  CAS  ADS  Google Scholar 

  7. Shaw, P. E. EMBO Rep. 3, 521–526 (2002).

    Article  CAS  Google Scholar 

  8. Lu, K. P., Hanes, S. D. & Hunter, T. Nature 380, 544–547 (1996).

    Article  CAS  ADS  Google Scholar 

  9. Rippmann, J. F. et al. Cell Growth Differ. 11, 409–416 (2000).

    CAS  Google Scholar 

  10. Liou, Y. C. et al. Proc. Natl Acad. Sci. USA 99, 1335–1340 (2002).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Kevin M. Ryan or Karen H. Vousden.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ryan, K., Vousden, K. Pinning a change on p53. Nature 419, 795–797 (2002).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing