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Pinning a change on p53

An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.

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Figure 1: Regulation of p53 protein by Pin1, as suggested by the results of Zheng et al.1 and Zacchi et al.2.


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Correspondence to Kevin M. Ryan or Karen H. Vousden.

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Ryan, K., Vousden, K. Pinning a change on p53. Nature 419, 795–797 (2002).

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