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Cell biology

Survival in three dimensions

Whether a cell lives or dies depends on various local cues. New work reveals that those cues include a cell's spatial relationship with its neighbours and polarized interactions with the adjacent extracellular matrix.

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Figure 1: Three-dimensional cell organization and polarity regulate sensitivity to drug-induced apoptosis — a summary of the results of Weaver et al.2.


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Correspondence to Kenneth M. Yamada or Katherine Clark.

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Yamada, K., Clark, K. Survival in three dimensions. Nature 419, 790–791 (2002).

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