Figure 1: Tumour evasion of the immune system. | Nature

Figure 1: Tumour evasion of the immune system.

From: Catch us if you can

Figure 1

a, NKG2D ligands such as MIC are often induced in cells by 'stress' — viral infection, for instance, or transformation of the cell into a tumour cell. The result should be that the cell becomes more susceptible to killing by cytotoxic T lymphocytes (CTLs): NKG2D probably works as a receptor that co-stimulates the T-cell receptor (not shown) through the DAP10 signalling chain. b, As Groh et al.1 demonstrate, there are soluble forms of MIC circulating in the blood of patients with MIC-expressing tumours which can affect NKG2D function by blocking recognition of membrane-bound MIC by CTLs and downregulating NKG2D expression. The result is that the CTL effectively becomes blind to the presence of the tumour.

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