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Cell biology

Unchaining the condemned

Like prisoners, condemned intracellular proteins are shackled with chains to await their fate. These chains are a signal that the proteins must be destroyed and are removed on protein degradation. New work shows how.

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Figure 1: The proteasome — the cellular protein executioner.


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Correspondence to Keith D. Wilkinson.

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Wilkinson, K. Unchaining the condemned. Nature 419, 351–353 (2002).

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