Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DNA repair

Right on target with ubiquitin

Nature volume 419, pages 120–121 (2002)Cite this article

Cellular DNA-repair mechanisms prevent mutations from accumulating, thereby averting defects in cell function. A molecule best known for its role in protein degradation is now shown to have a specific task in DNA repair.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Connecting DNA repair and ubiquitin, through the PCNA protein.

References

  1. Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425–479 (1998).

    Article  CAS  Google Scholar 

  2. Pickart, C. M. Trends Biochem. Sci. 25, 544–548 (2000).

    Article  CAS  Google Scholar 

  3. Reynolds, P., Weber, S. & Prakash, L. Proc. Natl Acad. Sci. USA 82, 168–172 (1985).

    Article  ADS  CAS  Google Scholar 

  4. Jentsch, S., McGrath, J. P. & Varshavsky, A. Nature 329, 131–134 (1987).

    Article  ADS  CAS  Google Scholar 

  5. Hoege, C., Pfander, B., Moldovan, G.-L, Pyrowolakis, G. & Jentsch, S. Nature 419, 135–141 (2002).

    Article  ADS  CAS  Google Scholar 

  6. Hoeijmakers, J. H. J. Nature 411, 366–374 (2001).

    Article  ADS  CAS  Google Scholar 

  7. Broomfield, S., Hryciw, T. & Xiao, W. Mutat. Res. 486, 167–184 (2001).

    Article  CAS  Google Scholar 

  8. Spence, J., Sadis, S., Haas, A. L. & Finley, D. Mol. Cell. Biol. 15, 1265–1273 (1995).

    Article  CAS  Google Scholar 

  9. Warbrick, E. BioEssays 22, 997–1006 (2000).

    Article  CAS  Google Scholar 

  10. Hochstrasser, M. Nature Cell Biol. 2, E153–E157 (2000).

    Article  CAS  Google Scholar 

  11. Desterro, J. M., Rodriguez, M. S. & Hay, R. T. Mol. Cell 2, 233–239 (1998).

    Article  CAS  Google Scholar 

  12. Ulrich, H. D. & Jentsch, S. EMBO J. 19, 3388–3397 (2000).

    Article  CAS  Google Scholar 

  13. Torres-Ramos, C., Yoder, B. L., Bugers, P. M. J., Prakash, S. & Prakash, L. Proc. Natl Acad. Sci. USA 93, 9676–9681 (1996).

    Article  ADS  CAS  Google Scholar 

  14. Torres-Ramos, C. A., Prakash, S. & Prakash, L. J. Biol. Chem. 272, 25445–25448 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, 21205, Maryland, USA

    Cecile M. Pickart

Authors
  1. Cecile M. Pickart
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cecile M. Pickart.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pickart, C. Right on target with ubiquitin. Nature 419, 120–121 (2002). https://doi.org/10.1038/419120a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/419120a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing