When faced with foreign molecules our antibodies mutate, allowing them to bind to the intruders more strongly. In a story full of surprises, it looks as though the mechanism of mutation has finally been revealed.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients
Scientific Reports Open Access 27 September 2016
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Di Noia, J. & Neuberger, M. S. Nature 419, 43–48 (2002); advance online publication, 31 July 2002 (doi:10.1038/nature00981).
Muramatsu, M. et al. Cell 102, 553–563 (2000).
Petersen-Mahrt, S. K., Harris, R. S. & Neuberger, M. S. Nature 418, 99–103 (2002).
Bross, L., Muramatsu, M., Kinoshita, K., Honjo, T. & Jacobs, H. J. Exp. Med. 195, 1187–1192 (2002).
Papavasiliou, F. N. & Schatz, D. G. J. Exp. Med. 195, 1193–1198 (2002).
Bebenek, K. et al. Science 291, 2156–2159 (2001).
Frank, E. G. et al. EMBO J. 20, 2914–2922 (2001).
Zeng, X. et al. Nature Immunol. 2, 537–541 (2001).
Pavlov, Y. I. et al. Proc. Natl Acad. Sci. USA 99, 9954–9959 (2002).
Phung, Q. H. et al. J. Exp. Med. 187, 1745–1751 (1998).
Wiesendanger, M., Kneitz, B., Edelmann, W. & Scharff, M. D. J. Exp. Med. 191, 579–584 (2000).
Diaz, M., Verkoczy, L. K., Flajnik, M. F. & Klinman, N. R. J. Immunol. 167, 327–335 (2001).
Peters, A. & Storb, U. Immunity 4, 57–65 (1996).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gearhart, P. The roots of antibody diversity. Nature 419, 29–31 (2002). https://doi.org/10.1038/419029a
Issue Date:
DOI: https://doi.org/10.1038/419029a
This article is cited by
-
Mechanisms and consequences of sex differences in immune responses
Nature Reviews Nephrology (2024)
-
Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients
Scientific Reports (2016)