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Apoptosis

Sculpture of a fly's head

Nature volume 418, pages 926–927 (2002)Cite this article

Hox proteins are needed during development to produce body segments with different shapes and functions. In fruitflies, one Hox protein sculpts certain segments of the head by activating a cell-death-inducing gene.

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Figure 1: Focal point for the control of cell death: the reaper (rpr) gene is activated in all fruitfly cells fated to die.

References

  1. Jacobson, M. D., Weil, M. & Raff, M. C. Cell 88, 347–354 (1997).

    Article  CAS  PubMed  Google Scholar 

  2. Hengartner, M. O. Nature 407, 770–776 (2000).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Lohmann, I., McGinnis, N., Bodmer, M. & McGinnis, W. Cell 110, 457–466 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Bangs, P. & White, K. Dev. Dyn. 218, 68–79 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Shi, Y. Mol. Cell 9, 459–470 (2002).

    Article  CAS  PubMed  Google Scholar 

  6. Jiang, C., Lamblin, A. F., Steller, H. & Thummel, C. S. Mol. Cell 5, 445–455 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Nordstrom, W. & Abrams, J. M. Cell Death Differ. 7, 1035–1038 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Mann, R. S. & Morata, G. Annu. Rev. Cell. Dev. Biol. 16, 243–271 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Nassif, C., Daniel, A., Lengyel, J. A. & Hartenstein, V. Dev. Biol. 197, 170–186 (1998).

    Article  CAS  PubMed  Google Scholar 

  10. White, K. et al. Science 264, 677–683 (1994).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Gavalas, A., Davenne, M., Lumsden, A., Chambon, P. & Rijli, F. M. Development 124, 3693–3702 (1997).

    CAS  PubMed  Google Scholar 

  12. Stadler, H. S., Higgins, K. M. & Capecchi, M. R. Development 128, 4177–4188 (2001).

    CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. the Division of Biology, MC156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, 91125, California, USA

    Jun R. Huh & Bruce A. Hay

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  1. Jun R. Huh
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  2. Bruce A. Hay
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Correspondence to Bruce A. Hay.

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Huh, J., Hay, B. Sculpture of a fly's head. Nature 418, 926–927 (2002). https://doi.org/10.1038/418926a

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