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Signal transduction

Positive feedback from coffee

Caffeine acts on our nerve cells to wake us up. It turns out that it does so through a molecular signalling pathway that involves a positive feedback loop, boosting caffeine's effects from inside the cell.

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Figure 1: How coffee wakes up your nerve cells, based on work by Lindskog et al.1.


  1. Lindskog, M. et al. Nature 418, 774–778 (2002).

    Article  CAS  Google Scholar 

  2. Fredholm, B. B., Battig, K., Holmen, J., Nehlig, A. & Zvartau, E. E. Pharmacol. Rev. 51, 83–133 (1999).

    CAS  PubMed  Google Scholar 

  3. Svenningsson, P., Nomikos, G. G. & Fredholm, B. B. J. Neurosci. 15, 7612–7624 (1995).

    Article  CAS  Google Scholar 

  4. Ledent, C. et al. Nature 388, 674–678 (1997).

    Article  CAS  Google Scholar 

  5. Chen, J.-F et al. J. Neurosci. 21, RC143 (1995).

    Article  Google Scholar 

  6. Greengard, P. Science 294, 1024–1030 (2001).

    Article  CAS  Google Scholar 

  7. Svenningsson, P. et al. Proc. Natl Acad. Sci. USA 97, 1856–1860 (2000).

    Article  CAS  Google Scholar 

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Correspondence to Jean-Marie Vaugeois.

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Vaugeois, JM. Positive feedback from coffee. Nature 418, 734–736 (2002).

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