Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Mass tool for diagnosis

Efficient and sensitive methods to determine whether, and to what extent, a person is infected with malaria should help to improve treatment. A high-tech approach, using mass spectrometry, may be the answer.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: In the blood — the malaria parasite (brown) in a sectioned human red blood cell (green).



  1. Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F. & Whitehouse, C. M. Science 246, 64–71 (1989).

    CAS  Article  Google Scholar 

  2. Hillenkamp, F., Karas, M., Beavis, R. C. & Chait, B. T. Anal. Chem. 63, 1193A–1202A (1991).

    CAS  Article  Google Scholar 

  3. Mann, M., Hendrickson, R. C. & Pandey, A. Annu. Rev. Biochem. 70, 437–473 (2001).

    CAS  Article  Google Scholar 

  4. Demirev, P. A. et al. Anal. Chem. 74, 3262–3266 (2002).

    CAS  Article  Google Scholar 

  5. Nature Insight: Malaria. Nature 415, 669–715 (2002).

  6. Moody, A. Clin. Microbiol. Rev. 15, 66–78 (2002).

    CAS  Article  Google Scholar 

  7. Cotter, R. J., Fancher, C. & Cornish, T. J. J. Mass Spectrom. 34, 1368–1372 (1999).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Matthias Mann.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mann, M. Mass tool for diagnosis. Nature 418, 731–732 (2002).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing