HIV cannot multiply in certain human cells unless it expresses a protein called Vif, the function of which has finally been revealed. It seems that it overcomes a human protein that would otherwise block viral replication.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Fisher, A. G. et al. Science 237, 888–893 (1987).
Strebel, K. et al. Nature 328, 728–773 (1987).
Sheehy, A. M., Gaddis, N. C., Choi, J. D. & Malim, M. H. Nature 418, 646–650 (2002); advance online publication, 14 July 2002 (doi:10.1038/nature00939).
von Schwedler, U., Song, J., Aiken, C. & Trono, D. J. Virol. 67, 4945–4955 (1993).
Gabuzda, D. H. et al. J. Virol. 66, 6489–6495 (1992).
Goncalves, J., Korin, Y., Zack, J. & Gabuzda, D. J. Virol. 70, 8701–8709 (1996).
Dornadula, G., Yang, S., Pomerantz, R. J. & Zhang, H. J. Virol. 74, 2594–2602 (2000).
Zhang, H., Pomerantz, R. J., Dornadula, G. & Sun, Y. J. Virol. 74, 8252–8261 (2000).
Khan, M. A. et al. J. Virol. 75, 7252–7265 (2001).
Dettenhofer, M., Cen, S., Carlson, B. A., Kleinum, L. & Yu, X.-F J. Virol. 74, 8938–8945 (2000).
Madani, N. & Kabat, D. J. Virol. 72, 10251–10255 (1998).
Simon, J. H. M., Gaddis, N. C., Fouchier, R. A. M. & Malim, M. H. Nature Med. 4, 1397–1400 (1998).
Pryciak, P. M. & Varmus, H. E. J. Virol. 66, 5959–5966 (1992).
Bhattacharya, S., Navaratnam, N., Morrison, J. R., Scott, J. & Taylor, W. R. Trends Biochem. Sci. 19, 105–106 (1994).
Novina, C. D. et al. Nature Med. 8, 681–686 (2002).
Jacque, J.-M, Triques, K. & Stevenson, M. Nature 418, 435–438 (2002); advance online publication, 26 June 2002 (doi:10.1038/nature00896).
Pomerantz, R. J. Nature Med. 8, 659–660 (2002).
Yang, S. C., Sun, Y. & Zhang, H. J. Biol. Chem. 276, 4889–4893 (2001).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pomerantz, R. A tough viral nut to crack. Nature 418, 594–595 (2002). https://doi.org/10.1038/418594a
Issue Date:
DOI: https://doi.org/10.1038/418594a
This article is cited by
-
Biological robustness
Nature Reviews Genetics (2004)