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Silencing viruses with RNA

Our cells have a built-in mechanism for 'silencing' genes, called RNA interference. This capability has now been exploited to protect cells in culture dishes from HIV-1 and poliovirus.

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Figure 1: RNA interference — a tool for cells as well as scientists.

References

  1. Gitlin, L., Karelsky, S. & Andino, R. Nature 418, 430–434 (2002); advance online publication, 26 June 2002 (doi:10.1038/nature00873).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Jacque, J.-M, Triques, K. & Stevenson, M. Nature 418, 435–438 (2002); advance online publication, 26 June 2002 (doi:10.1038/nature00896).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Novina, C. D. et al. Nature Med. 8, 681–686 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Sharp, P. A. Genes Dev. 15, 485–490 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Parrish, S., Fleenor, J., Xu, S., Mello, C. & Fire, A. Mol. Cell 6, 1077–1087 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Nykanen, A., Haley, B. & Zamore, P. D. Cell 107, 309–321 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Zamore, P. D., Tuschl, T., Sharp, P. A. & Bartel, D. P. Cell 101, 25–33 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J. & Conklin, D. S. Genes Dev. 16, 948–958 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Brummelkamp, T. R., Bernards, R. & Agami, R. Science 296, 550–553 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Yu, J.-Y, DeRuiter, S. L. & Turner, D. L. Proc. Natl Acad. Sci. USA 99, 6047–6052 (2002).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  11. Bitko, V. & Barik, S. BMC Microbiol. 1, 34 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lee, N. S. et al. Nature Biotechnol. 20, 500–505 (2002).

    Article  CAS  Google Scholar 

  13. Elbashir, S. M. et al. Nature 411, 494–498 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Harborth, J., Elbashir, S. M., Bechert, K., Tuschl, T. & Weber, K. J. Cell Sci. 114, 4557–4565 (2001).

    CAS  PubMed  Google Scholar 

  15. Baltimore, D. Nature 335, 395–396 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Gordon G. Carmichael.

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Carmichael, G. Silencing viruses with RNA. Nature 418, 379–380 (2002). https://doi.org/10.1038/418379a

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