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Gene expression

RNA interference in adult mice


RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.

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Figure 1: RNA interference in adult mice.


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Correspondence to Mark A. Kay.

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The authors declare no competing financial interests.

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McCaffrey, A., Meuse, L., Pham, TT. et al. RNA interference in adult mice. Nature 418, 38–39 (2002).

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