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Left–right development

Conserved function for embryonic nodal cilia

A similar mechanism may underlie the handedness seen in all vertebrate body plans.

Abstract

How left–right handedness originates in the body plan of the developing vertebrate embryo is a subject of considerable debate1,2. In mice, a left–right bias is thought to arise from a directional extracellular flow (nodal flow) that is generated by dynein-dependent rotation of monocilia on the ventral surface of the embryonic node3,4. Here we show that the existence of node monocilia and the expression of a dynein gene that is implicated in ciliary function are conserved across a wide range of vertebrate classes, indicating that a similar ciliary mechanism may underlie the establishment of handedness in all vertebrates.

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Figure 1: Regions of potential left–right signalling in mouse, chick, Xenopus and zebrafish.

References

  1. 1

    Capdevila, J. et al. Cell 101, 9–21 (2000).

    CAS  Article  Google Scholar 

  2. 2

    Wright, C. V. E. Dev. Cell 1, 179–186 (2001).

    CAS  Article  Google Scholar 

  3. 3

    Nonaka, S. et al. Cell 95, 829–837 (1998).

    CAS  Article  Google Scholar 

  4. 4

    Okada, Y. et al. Mol. Cell 4, 459–468 (1999).

    CAS  Article  Google Scholar 

  5. 5

    Supp, D. M. et al. Nature 389, 963–966 (1997).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Supp, D. M. et al. Development 126, 5495–5504 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. 7

    Olbrich, H. et al. Nature Genet. 30, 143–144 (2002).

    CAS  Article  Google Scholar 

  8. 8

    Männer, J. Anat. Embryol. 203, 481–490 (2001).

    Article  Google Scholar 

  9. 9

    Cooper, M. S. & D'Amico, L. A. Dev. Biol. 180, 184–198 (1996).

    CAS  Article  Google Scholar 

Download references

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Correspondence to H. Joseph Yost.

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The authors declare no competing financial interests.

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Essner, J., Vogan, K., Wagner, M. et al. Conserved function for embryonic nodal cilia. Nature 418, 37–38 (2002). https://doi.org/10.1038/418037a

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