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Pest Control

Caffeine as a repellent for slugs and snails

At high concentrations this stimulant becomes a lethal neurotoxin to garden pests.


Most commercial products for snail and slug control contain either metaldehyde or methiocarb as the active ingredient1, the residues of which are not permitted in food crops in the United States2. We have discovered that solutions of caffeine are effective in killing or repelling slugs and snails when applied to foliage or the growing medium of plants. Because caffeine is a natural product and is classified by the US Food and Drug Administration as a GRAS ('generally recognized as safe') compound3, it has potential as an environmentally acceptable alternative toxicant for the control of slugs and snails on food crops.

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Figure 1: Repulsion of slugs (Veronicella cubensis (Pfeiffer)) by caffeine-sprayed leaves.
Figure 2: Effect of caffeine on the orchid snail Zonitoides arboreus (Say).

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  1. Martin, A. Outlook Agric. 20, 167–174 (1991).

    Article  Google Scholar 

  2. US Code of Federal Regulations. Title 40 — Protection of Environment (40CFR180.523) 479 (US Government, 2001).

  3. US Code of Federal Regulations. Title 21 — Food and Drugs (21CFR182) 455 (US Government, 2001).

  4. Fahim, M. A. & Usherwood, P. N. R. J. Neurobiol. 14, 391–397 (1983).

    Article  CAS  Google Scholar 

  5. Moffett, D. F., Smith, C. J. & Green, J. M. Comp. Biochem. Physiol. 75, 305–310 (1983).

    Google Scholar 

  6. Ahmed, I. A., Hopkins, P. M. & Winlow, W. Gen. Pharmacol. 28, 245–250 (1997).

    Article  CAS  Google Scholar 

  7. Cook, B. J. & Holman, G. M. Comp. Biochem. Physiol. 67, 115–120 (1980).

    Google Scholar 

  8. Nathanson, J. A. Science 226, 184–187 (1984).

    Article  ADS  CAS  Google Scholar 

  9. Wilkins, R. M., Saleem, M. A. & Candasamy, R. Pestic. Sci. 43, 321–331 (1995).

    Article  CAS  Google Scholar 

  10. Ahmed, I. A., Hopkins, P. M. & Winlow, W. Comp. Biochem. Physiol. 105, 363–372 (1993).

    Article  Google Scholar 

  11. Windholz, M. (ed.) The Merck Index 9th edn (Merck, Rahway, New Jersey, 1976).

  12. Steel, R. G. D. & Torrie, J. H. Principles and Procedures of Statistics (McGraw-Hill, New York, 1980).

  13. SAS/STAT User's Guide 6.03 Chs 20, 24 (SAS Institute, Cary, North Carolina, 1988).

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Correspondence to Robert G. Hollingsworth.

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The authors declare no competing financial interests.

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Hollingsworth, R., Armstrong, J. & Campbell, E. Caffeine as a repellent for slugs and snails. Nature 417, 915–916 (2002).

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