Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Developmental neurobiology

Cortical liars

Inhibitory cells known as interneurons constitute a significant proportion of the neurons in the neocortex of mammalian brains. As far as interneuron origins are concerned, humans may be the odd man out.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Interneuron origins in the embryonic brain.


  1. Letinic, K., Zoncu, R. & Rakic, P. Nature 417, 645–649 (2002).

    Article  ADS  CAS  Google Scholar 

  2. Maricich, S. M., Gilmore, E. C. & Herrup, K. Neuron 31, 175–178 (2001).

    Article  CAS  Google Scholar 

  3. Rakic, P. Proc. Natl Acad. Sci. USA 92, 11323–11327 (1995).

    Article  ADS  CAS  Google Scholar 

  4. Mione, M. C., Cavanagh, J. F. R., Harris, B. & Parnavelas, J. G. J. Neurosci. 17, 2018–2029 (1997).

    Article  CAS  Google Scholar 

  5. Tan, S.-S et al. Neuron 21, 295–304 (1998).

    Article  CAS  Google Scholar 

  6. Anderson, S. A., Eisenstat, D. D., Shi, L. & Rubenstein, J. L. Science 278, 474–476 (1997).

    Article  ADS  CAS  Google Scholar 

  7. Marin, O. & Rubenstein, J. L. Nature Rev. Neurosci. 2, 780–790 (2001).

    Article  CAS  Google Scholar 

  8. Letinic, K. & Rakic, P. Nature Neurosci. 4, 931–936 (2001).

    Article  CAS  Google Scholar 

  9. Nieto, M., Schuurmans, C., Britz, O. & Guillemot, F. Neuron 29, 401–413 (2001).

    Article  CAS  Google Scholar 

  10. Fode, C. et al. Genes Dev. 14, 67–80 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Nadarajah, B., Alifragis, P., Wong, R. O. & Parnavelas, J. G. Nature Neurosci. 5, 218–224 (2002).

    Article  CAS  Google Scholar 

  12. Finlay, B. L. & Darlington, R. B. Science 268, 1578–1584 (1995).

    Article  ADS  CAS  Google Scholar 

  13. Benes, F. M. & Berretta, S. Neuropsychopharmacology 25, 1–27 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Seong-Seng Tan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tan, SS. Cortical liars. Nature 417, 605–606 (2002).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing