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Circadian rhythms from flies to human

Naturevolume 417pages329335 (2002) | Download Citation



In this era of jet travel, our body 'remembers' the previous time zone, such that when we travel, our sleep–wake pattern, mental alertness, eating habits and many other physiological processes temporarily suffer the consequences of time displacement until we adjust to the new time zone. Although the existence of a circadian clock in humans had been postulated for decades, an understanding of the molecular mechanisms has required the full complement of research tools. To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila.

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  1. Department of Cell Biology, The Scripps Research Institute, La Jolla, 92037, California, USA

    • Satchidananda Panda
    •  & Steve A. Kay
  2. Genomics Institute of Novartis Research Foundation, San Diego, 92121, California, USA

    • Satchidananda Panda
    • , John B. Hogenesch
    •  & Steve A. Kay


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Correspondence to Steve A. Kay.

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