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Ion channels

How to be desensitized

The various functional states of glutamate receptors control much of the brain's neuronal activity. Our understanding of how one of those states — desensitization — occurs has taken a leap forward.

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Figure 1: Activation and desensitization of AMPA-type glutamate receptors.

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Correspondence to Christian Rosenmund.

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Rosenmund, C., Mansour, M. How to be desensitized. Nature 417, 238–239 (2002). https://doi.org/10.1038/417238a

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