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Amyloid diseases

Small drugs lead the attack

Many human disorders — a well-known example being Alzheimer's disease — are characterized by the misfolding and aggregation of key proteins. New small-molecule drugs may help to destabilize these aggregates.

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Figure 1: Structure of the pentamer of the serum amyloid P protein (SAP)13.

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Correspondence to Leslie Iversen.

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Iversen, L. Small drugs lead the attack. Nature 417, 231–233 (2002). https://doi.org/10.1038/417231a

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