Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Developmental biology

Modular feedback

To understand cell signalling during development, we need to know how whole signalling networks — not just their individual components — are regulated. Two new studies highlight this point.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The fibroblast growth factor (FGF) synexpression group.
Figure 2: Negative feedback as an essential tool for generating appropriate behaviour of signalling systems.

References

  1. Tsang, M., Friesel, R., Kudoh, T. & Dawid, I. B. Nature Cell Biol. 4, 165–169 (2002).

    Article  CAS  Google Scholar 

  2. Fürthauer, M., Lin, W., Ang, S. L., Thisse, B. & Thisse, C. Nature Cell Biol. 4, 170–174 (2002).

    Article  Google Scholar 

  3. Fürthauer, M., Reifers, F., Brand, M., Thisse, B. & Thisse, C. Development 128, 2175–2186 (2001).

    PubMed  Google Scholar 

  4. Raible, F. & Brand, M. Mech. Dev. 107, 105–117 (2001).

    Article  CAS  Google Scholar 

  5. Niehrs, C. & Pollet, N. Nature 402, 483–487 (1999).

    Article  ADS  CAS  Google Scholar 

  6. Onichtchouk, D. et al. Nature 401, 480–485 (1999).

    Article  ADS  CAS  Google Scholar 

  7. Lamar, E. et al. Genes Dev. 15, 1885–1899 (2001).

    Article  CAS  Google Scholar 

  8. Jen, W.-C, Gawantka, V., Pollet, N., Niehrs, C. & Kintner, C. Genes Dev. 13, 1486–1499 (1999).

    Article  CAS  Google Scholar 

  9. http://www.eb.tuebingen.mpg.de/abt.4/meinhardt/theory.html

  10. Becskei, A. & Serrano, L. Nature 405, 590–593 (2000).

    Article  ADS  CAS  Google Scholar 

  11. Elowitz, M. B. & Leibler, S. Nature 403, 335–338 (2000).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Niehrs, C., Meinhardt, H. Modular feedback. Nature 417, 35–36 (2002). https://doi.org/10.1038/417035a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/417035a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing