Nature 412, 914–917 (2001).
Some background information to our work on adeno-associated virus (AAV)-induced apoptosis in cells lacking p53 activity was omitted owing to space constraints. The oncosuppressive activity of parvoviruses has been reviewed1,2. AAV inhibits cell cycle progression3, even when ultraviolet-inactivated4, as do AAV-coded Rep proteins5. p53-dependent cytopathic effects of parvovirus H1 have been reported6. H1 is an autonomous virus that can replicate in cells and lyse them. This is different from AAV, which is defective and does not replicate in the conditions we used. H1 and AAV share little sequence homology and the structures of the DNA termini are not the same.
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Raj, K., Ogston, P. & Beard, P. addendum: Virus-mediated killing of cells that lack p53 activity. Nature 416, 202 (2002). https://doi.org/10.1038/416202a
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DOI: https://doi.org/10.1038/416202a
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