Just as important as starting cellular signalling pathways is switching them off again. It seems that the Cbl protein has a dual function in accelerating the degradation of certain signalling molecules.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W. Y. & Dikic, I. Nature 416, 183–187 (2002).
Petrelli, A. et al. Nature 416, 187–190 (2002).
Yoon, C. H., Lee, J., Jongeward, G. D. & Sternberg, P. W. Science 269, 1102–1105 (1995).
Thien, C. B. & Langdon, W. Y. Nature Rev. Mol. Cell Biol. 2, 294–307 (2001).
Hicke, L. & Riezman, H. Cell 84, 277–287 (1996).
Ringstad, N. et al. Neuron 24, 143–154 (1999).
Schmidt, A. et al. Nature 401, 133–141 (1999).
Farsad, K. et al. J. Cell Biol. 155, 193–200 (2001).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Oved, S., Yarden, Y. Molecular ticket to enter cells. Nature 416, 133–136 (2002). https://doi.org/10.1038/416133a
Issue Date:
DOI: https://doi.org/10.1038/416133a
This article is cited by
-
Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA
Cellular and Molecular Life Sciences (2018)
-
Structural Systems Biology and Multiscale Signaling Models
Annals of Biomedical Engineering (2012)
-
MET signalling: principles and functions in development, organ regeneration and cancer
Nature Reviews Molecular Cell Biology (2010)
-
Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation
EMBO reports (2005)
-
Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
Nature Immunology (2003)
