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Developmental biology

Senseless motion

Rhythmic movements such as locomotion are produced by oscillatory circuits in the central nervous system. Work in fruitflies shows that the neural circuitry for such movements develops without peripheral sensory feedback.

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Figure 1: Embryo waves — peristaltic motion in a late-stage fruitfly embryo, just before hatching.



  1. Fénelon, V. S., Casasnovas, B., Simmers, J. & Meyrand, P. Curr. Opin. Neurobiol. 8, 705–709 (1998).

    Article  Google Scholar 

  2. Bate, M. Curr. Opin. Neurobiol. 9, 670–675 (1999).

    Article  CAS  Google Scholar 

  3. O'Donovan, M. J. Curr. Opin. Neurobiol. 9, 94–104 (1999).

    Article  CAS  Google Scholar 

  4. Marder, E. Nature 410, 755 (2001).

  5. Bekoff, A., Nusbaum, M. P., Sabichi, A. L. & Clifford, M. J. Neurosci. 7, 2320–2330 (1987).

    CAS  PubMed  Google Scholar 

  6. Suster, M. L. & Bate, M. Nature 416, 174–178 (2002).

    Article  ADS  CAS  Google Scholar 

  7. Nolo, R., Abbott, L. A. & Bellen, H. J. Cell 102, 349–362 (2000).

    Article  CAS  Google Scholar 

  8. Marder, E. & Bucher, D. Curr. Biol. 11, R986–R996 (2001).

  9. Pearson, K. G. Curr. Opin. Neurobiol. 5, 786–791 (1995).

    Article  CAS  Google Scholar 

  10. Goldman, M. S., Golowasch, J., Marder, E. & Abbott, L. F. J. Neurosci. 21, 5229–5238 (2001).

    Article  CAS  Google Scholar 

  11. Golowasch, J., Casey, M., Abbott, L. F. & Marder, E. Neural Comput. 11, 1079–1096 (1999).

    Article  CAS  Google Scholar 

  12. Baines, R. A., Uhler, J. P., Thompson, A., Sweeney, S. T. & Bate, M. J. Neurosci. 21, 1523–1531 (2001).

    Article  CAS  Google Scholar 

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Correspondence to Eve Marder.

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Marder, E. Senseless motion. Nature 416, 131–132 (2002).

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