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Cell biology

Ripping up the nuclear envelope

During cell division, the membranes that surround the nucleus must be dismantled to allow the DNA housed inside the nucleus to be partitioned into two daughter cells. New work shows how this happens.

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Figure 1: How cells dismantle the nuclear envelope during the phases (shown in boxes) of cell division, as proposed by Beaudouin et al.2 and Salina et al.3.


  1. Gerace, L. & Burke, B. Annu. Rev. Cell Biol. 4, 335–374 (1988).

    CAS  Article  Google Scholar 

  2. Beaudouin, J., Gerlich, D., Daigle, N., Eils, R. & Ellenberg, J. Cell 108, 83–96 (2002).

    CAS  Article  Google Scholar 

  3. Salina, D. et al. Cell 108, 97–107 (2002).

    CAS  Article  Google Scholar 

  4. Collas, I. & Courvalin, J. C. Trends Cell Biol. 10, 5–8 (2000).

    CAS  Article  Google Scholar 

  5. Ellenberg, J. et al. J. Cell Biol. 138, 1193–1206 (1997).

    CAS  Article  Google Scholar 

  6. Terasaki, M. et al. Mol. Biol. Cell 12, 503–510 (2001).

    CAS  Article  Google Scholar 

  7. Robbins, E. & Gonatas, N. K. J. Cell Biol. 21, 429–463 (1964).

    CAS  Article  Google Scholar 

  8. Georgatos, S. D., Pyrpasopoulou, D. & Theodoropoulos, P. A. J. Cell Sci. 110, 2129–2140 (1997).

    CAS  PubMed  Google Scholar 

  9. Karki, S. & Holzbaur, E. L. Curr. Opin. Cell Biol. 11, 45–53 (1999).

    CAS  Article  Google Scholar 

  10. DeMatteis, M. A. & Morrow, J. S. J. Cell Sci. 113, 2331–2343 (2000).

    CAS  Google Scholar 

  11. Addinall, S. G. et al. J. Biol. Chem. 276, 15939–15944 (2001).

    CAS  Article  Google Scholar 

  12. Zaal, K. J. M. et al. Cell 99, 589–601 (1999).

    CAS  Article  Google Scholar 

  13. Shima, D. T. et al. J. Cell Biol. 141, 955–966 (1998).

    CAS  Article  Google Scholar 

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Correspondence to Jennifer Lippincott-Schwartz.

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Lippincott-Schwartz, J. Ripping up the nuclear envelope. Nature 416, 31–32 (2002).

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