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Nuclear transplantation

A monoclonal mouse?

One potential use of nuclear-transplantation — cloning — technology is to generate genetically matched tissues for treating adult patients. But there's a debate about whether mature adult cells are a good source of nuclei.

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Figure 1: Hochedlinger and Jaenisch's technique1 for generating cloned mice, using nuclei from mature immune cells.


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Correspondence to Janet Rossant.

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Rossant, J. A monoclonal mouse?. Nature 415, 967–969 (2002).

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