Obesity and a rare, congenital absence of fat cells are associated with damaging levels of fat in various tissues, and diabetes. Leptin helps to remedy these problems by causing oxidation of fatty acids in mitochondria.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Cadmium: An Emerging Role in Adipose Tissue Dysfunction
Exposure and Health Open Access 10 September 2021
-
Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway
Cell Death Discovery Open Access 22 August 2016
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Friedman, J. M. Harvey Lecture 95, 107–136 (1999–2000).
Minokoshi, Y. et al. Nature 415, 339–343 (2002).
Randle, P. J. Diabetes Metab. Rev. 14, 263–283 (1998).
McGarry, J. D. Science 258, 766–770 (1992).
Shulman, G. I. J. Clin. Invest. 106, 171–176 (2000).
Unger, R. H., Zhou, Y.-T & Orci, L. Proc. Natl Acad. Sci. USA 96, 2327–2332 (1999).
Shimomura, I., Hammer, R., Ikemoto, S., Brown, M. & Goldstein, J. Nature 401, 73–76 (1999).
Shimabukuro, M. et al. Proc. Natl Acad. Sci. USA 94, 4637–4641 (1997).
Shimabukuro, M., Zhou, Y. T., Levi, M. & Unger, R. H. Proc. Natl Acad. Sci. USA 95, 2498–2502 (1998).
Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M. & Charron, M. J. Nature 389, 374–377 (1997).
Pelleymounter, M. A. et al. Science 269, 540–543 (1995).
McGarry, J. D., Mannaerts, G. P. & Foster, D. W. J. Clin. Invest. 60, 265–270 (1977).
Winder, W. W. & Hardie, D. G. Am. J. Physiol. 277, E1–E10 (1999).
Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H. & Wakil, S. J. Science 291, 2613–2616 (2001).
Heymsfield, S. et al. J. Am. Med. Assoc. 282, 1568–1575 (1999).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Friedman, J. Fat in all the wrong places. Nature 415, 268–269 (2002). https://doi.org/10.1038/415268a
Issue Date:
DOI: https://doi.org/10.1038/415268a
This article is cited by
-
Effect of Reduction Mammoplasty on Insulin and Lipid Metabolism in the Postoperative Third month: Compensatory Hip Enlargement
Aesthetic Plastic Surgery (2023)
-
Cadmium: An Emerging Role in Adipose Tissue Dysfunction
Exposure and Health (2022)
-
Reversal of intramyocellular lipid accumulation by lipophagy and a p62-mediated pathway
Cell Death Discovery (2016)
-
Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
Diabetologia (2011)
-
Effects of Post‐absorptive and Postprandial Exercise on Glucoregulation in Metabolic Syndrome
Obesity (2007)