The p53 protein works to suppress cancer, so one might think that bumping up the levels of this protein would be a good idea. But this isn't so — mice with too much p53 age prematurely.
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References
Vogelstein, B., Lane, D. & Levine, A. J. Nature 408, 307–310 (2000).
Donehower, L. A. et al. Nature 356, 215–221 (1992).
Tyner, S. D. et al. Nature 415, 45–53 (2002).
Hupp, T. R., Sparks, A. & Lane, D. P. Cell 83, 237–245 (1995).
Guarente, L. & Kenyon, C. Nature 408, 255–262 (2000).
Rudolph, K. L. et al. Cell 96, 701–712 (1999).
Szilard, L. Proc. Natl Acad. Sci. USA 45, 30–45 (1959).
Curtis, H. J. Science 141, 686–694 (1963).
Luo, J. et al. Cell 107, 137–148 (2001).
Vaziri, H. et al. Cell 107, 149–159 (2001).
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. & de Lange, T. Science 283, 1321–1325 (1999).
Chin, L. et al. Cell 97, 527–538 (1999).
Komarov, P. G. et al. Science 285, 1733–1737 (1999).
Campisi, J. Trends Cell Biol. 11, S27–S31 (2001).
Shelton, D. N., Chang, E., Whittier, P. S., Choi, D. & Funk, W. D. Curr. Biol. 9, 939–945 (1999).
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Ferbeyre, G., Lowe, S. The price of tumour suppression?. Nature 415, 26–27 (2002). https://doi.org/10.1038/415026a
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DOI: https://doi.org/10.1038/415026a
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