The much-studied Murchison meteorite is generally used as the standard reference for organic compounds in extraterrestrial material. Amino acids and other organic compounds1 important in contemporary biochemistry are thought to have been delivered to the early Earth by asteroids and comets, where they may have played a role in the origin of life2,3,4. Polyhydroxylated compounds (polyols) such as sugars, sugar alcohols and sugar acids are vital to all known lifeforms—they are components of nucleic acids (RNA, DNA), cell membranes and also act as energy sources. But there has hitherto been no conclusive evidence for the existence of polyols in meteorites, leaving a gap in our understanding of the origins of biologically important organic compounds on Earth. Here we report that a variety of polyols are present in, and indigenous to, the Murchison and Murray meteorites in amounts comparable to amino acids. Analyses of water extracts indicate that extraterrestrial processes including photolysis and formaldehyde chemistry could account for the observed compounds. We conclude from this that polyols were present on the early Earth and therefore at least available for incorporation into the first forms of life.
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Cronin, J. R. & Chang, S. in Chemistry of Life's Origins (eds Greenberg, J. M., Pirronello, V. & Mendoza-Gomez, C.) 209–258 (Kluwer, Dordrecht, 1993).
Oro, J. Comets and the formation of biochemical compounds on the primitive earth. Nature 190, 389–390 (1961).
Anders, E. Pre-biotic organic matter from comets and asteroids. Nature 342, 255–257 (1989).
Chyba, C. F. & Sagan, C. Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: an inventory for the origins of life. Nature 355, 125–132 (1992).
Degens, E. T. & Bajor, M. Amino acids and sugars in the Bruderheim and Murray meteorite. Naturwissenschaften 49, 605–606 (1962).
Kaplan, I. R., Degens, E. T. & Reuter, J. H. Organic compounds in stony meteorites. Geochim. Cosmochim. Acta 27, 805–834 (1963).
Hayes, J. M. Organic constituents of meteorites—a review. Geochim. Cosmochim. Acta 31, 1395–1440 (1967).
Amelung, W., Cheshire, M. V. & Guggenberger, G. Determination of neutral and acidic sugars in soil by capillary gas-liquid chromatography after trifluoroacetic acid hydrolysis. Soil Biol. Biochem. 28, 1631–1639 (1997).
Gilbart, J., Fox, A. & Morgan, S. L. Carbohydrate profiling of bacteria by gas chromatography-mass spectrometry: Chemical derivatization and analytical pyrolysis. Eur. J. Clin. Microbiol. 6, 715–723 (1987).
Brimacombe, J. S. & Webber, J. M. in The Carbohydrates, Chemistry and Biochemistry (eds Pigman, W. & Horton, D.) 479–518 (Academic, New York, 1972).
Pigman, W. & Anet, E. F. L. J. in The Carbohydrates, Chemistry and Biochemistry (eds Pigman, W. & Horton, D.) 165–194 (Academic, New York, 1972).
De Bruijn, J. M., Kieboom, A. P. G. & Van Bekkum, H. Reactions of monosaccharides in aqueous alkaline solutions. Sugar Tech. Rev. 13, 21–52 (1986).
Petersson, G. Mass spectrometry of aldonic and deoxyaldonic acids as trimethylsilyl derivatives. Tetrahedron 26, 3413–3428 (1970).
Agarwal, V. K. et al. Photochemical reactions in interstellar grain photolysis of CO, NH3, and H2O. Origins Life 16, 21–40 (1986).
McDonald, G. D. et al. Production and chemical analysis of cometary ice tholins. Icarus 122, 107–117 (1996).
Langenbeck, W. Die formaldehydkondensation als organische autokatalyse. Naturwissenschaften 30, 30–34 (1942).
Weber, A. L. Prebiotic sugars: hexose and hydroxy acid synthesis from glyceraldehyde catalyzed by iron (III) hydroxide oxide. J. Mol. Evol. 35, 1–6 (1992).
Bunch, T. E. & Chang, S. Carbonaceous chondrites–II. Carbonaceous chondrites phyllosilicates and light element geochemistry as indicators of parent body processes and surface conditions. Geochim. Cosmochim. Acta 44, 1543–1577 (1980).
Zolensky, M. & Mcsween, J. Y. in Meteorites and the Early Solar System (eds Kerridge, J. F. & Matthews, M. S.) 114–143 (Univ. Arizona Press, Tucson, 1988).
Irvine, W. M. The composition of interstellar molecular clouds. Space Sci. Rev. 90, 203–218 (1999).
Jungclaus, G. A., Yuen, G. U., Moore, C. B. & Lawless, J. G. Evidence for the presence of low molecular weight alcohols and carbonyl compounds in the Murchison meteorite. Meteoritics 11, 231–237 (1976).
Hollis, J. M., Lovas, F. J. & Jewell, P. R. Interstellar glycolaldehyde: the first sugar. Astrophys. J. 540, L107–L110 (2000).
Cody, G. D., Alexander, C. M. O'D. & Tera, F. New insights into the chemistry of Murchison organic macromolecule using high field 13C solid state NMR. Lunar Planet. Sci. Conf. XXX, 1582–1583 (1999).
Larralde, R., Robertson, M. P. & Miller, S. L. Rates of decomposition of ribose and other sugars: Implications for chemical evolution. Proc. Natl Acad. Sci. USA 92, 8158–8160 (1995).
Lowendahl, L., Petersson, G. & Samuelson, O. Formation of carboxylic acids by degradation of carbohydrates during kraft cooking of pine. Technic. Assoc. Pulp Paper Ind. 59, 118–120 (1976).
Cooper, G. W. & Cronin, J. R. Linear and cyclic aliphatic carboxamides of the Murchison meteorite: Hydrolyzable derivatives of amino acids and other carboxylic acids. Geochim. Cosmochim. Acta 59, 1003–1015 (1995).
Epstein, S., Krishnamurthy, R. V., Cronin, J. R., Pizzarello, S. & Yuen, G. U. Unusual stable isotope ratios in amino acid and carboxylic acid extracts from the Murchison meteorite. Nature 326, 477–479 (1987).
Coleman, M. L. & Moore, M. P. Direct reduction of sulfates to sulfur dioxide for isotopic analysis. Anal. Chem. 50, 1594–1595 (1978).
Des Marais, D. J. Isotopic evolution of the biogeochemical carbon cycle during the Proterozoic eon. Org. Geochem. 27, 185–193 (1997).
We thank A. Weber and J. Cronin for discussions and comments on the manuscript; and C. Asiyo and T. Esposito for assistance with figures. This work was supported by the Exobiology Program of NASA.
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Cooper, G., Kimmich, N., Belisle, W. et al. Carbonaceous meteorites as a source of sugar-related organic compounds for the early Earth. Nature 414, 879–883 (2001). https://doi.org/10.1038/414879a
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