Red wines confer extra benefit when it comes to preventing coronary heart disease.
Abstract
Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect1,2. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease3,4, there is no clear evidence that red wine confers an additional benefit5. Here we show that red wines strongly inhibit the synthesis of endothelin-1, a vasoactive peptide that is crucial in the development of coronary atherosclerosis6. Our findings indicate that components specific to red wine may help to prevent coronary heart disease.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Nanoparticles for the treatment of glaucoma-associated neuroinflammation
Eye and Vision Open Access 02 July 2022
-
The proanthocyanin-related transcription factors MYBC1 and WRKY44 regulate branch points in the kiwifruit anthocyanin pathway
Scientific Reports Open Access 25 August 2020
-
Alcoholic cardiomyopathy
Herz Open Access 31 August 2016
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
St Leger, A. S., Cochrane, A. L. & Moore, F. Lancet i, 1017–1020 (1979).
Renaud, S. & De Lorgeril, M. Lancet i, 1523–1526 (1992).
Doll, R., Peto, R., Hall, E., Wheatley, K. & Gray, R. Br. Med. J. 309, 911–918 (1994).
Law, M. & Wald, N. Br. Med. J. 318, 1471–1476 (1999).
Goldberg, I. J., Mosca, L., Piano, M.R. & Fisher, E. A. Circulation 103, 472–475 (2001).
Corder, R. in Handbook of Experimental Pharmacology: Endothelin and its Inhibitors (ed. Warner, T. D.) 152, 35–67 (Springer, Berlin, 2001).
Yanagisawa, M. et al. Nature 332, 411–415 (1988).
Caligiuri, G., Levy, B., Pernow, J., Thorén, P. & Hansson, G. K. Proc. Natl Acad. Sci. USA 96, 6920–6924 (1999).
Kinlay, S. et al. Circulation 104, 1114–1118 (2001).
Frankel, E. N., Kanner, J., German, J. B., Parks, E. & Kinsella, J. E. Lancet 341, 454–457 (1993).
Diebolt, M., Bucher, B. & Andriantsitohaina, R. Hypertension 38, 159–165 (2001).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Rights and permissions
About this article
Cite this article
Corder, R., Douthwaite, J., Lees, D. et al. Endothelin-1 synthesis reduced by red wine. Nature 414, 863–864 (2001). https://doi.org/10.1038/414863a
Issue Date:
DOI: https://doi.org/10.1038/414863a
This article is cited by
-
Nanoparticles for the treatment of glaucoma-associated neuroinflammation
Eye and Vision (2022)
-
The proanthocyanin-related transcription factors MYBC1 and WRKY44 regulate branch points in the kiwifruit anthocyanin pathway
Scientific Reports (2020)
-
Alcoholic cardiomyopathy
Herz (2016)
-
Weingenuss und Prävention der koronaren Herzkrankheit
Herz (2016)
-
Depressor action and vasorelaxation of methylene chloride fraction extracted from Rubus coreanum
Clinical Hypertension (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
