Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Decrease in hippocampal neurogenesis during pregnancy: a link to immunity

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1


  1. Buckwalter JG, Buckwalter DK, Bluestein BW, Stanczyk FZ . Pregnancy and post partum: changes in cognition and mood. Prog Brain Res 2001; 133: 303–319.

    Article  CAS  Google Scholar 

  2. Crawley RA, Dennison K, Carter C . Cognition in pregnancy and the first year post-partum. Psychol Psychother 2003; 76 (Part 1): 69–84.

    Article  CAS  Google Scholar 

  3. Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N et al. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci 2006; 9: 268–275.

    Article  CAS  Google Scholar 

  4. Leuner B, Mirescu C, Noiman L, Gould E . Maternal experience inhibits the production of immature neurons in the hippocampus during the postpartum period through elevations in adrenal steroids. Hippocampus 2007; 17: 434–442.

    Article  CAS  Google Scholar 

  5. van Praag H, Kempermann G, Gage FH . Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999; 2: 266–270.

    Article  CAS  Google Scholar 

  6. Kempermann G, van Praag H, Gage FH . Activity-dependent regulation of neuronal plasticity and self repair. Prog Brain Res 2000; 127: 35–48.

    Article  CAS  Google Scholar 

  7. Bick-Sander A, Steiner B, Wolf SA, Babu H, Kempermann G . Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring. Proc Natl Acad Sci USA 2006; 103: 3852–3857.

    Article  CAS  Google Scholar 

  8. Shingo T, Gregg C, Enwere E, Fujikawa H, Hassam R, Geary C et al. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 2003; 299: 117–120.

    Article  CAS  Google Scholar 

  9. Luppi P . How immune mechanisms are affected by pregnancy. Vaccine 2003; 21: 3352–3357.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to M Schwartz.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rolls, A., Schori, H., London, A. et al. Decrease in hippocampal neurogenesis during pregnancy: a link to immunity. Mol Psychiatry 13, 468–469 (2008).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links