Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

High mobility group box 1 and refeeding-resistance in anorexia nervosa

Molecular Psychiatry volume 12, pages 976–977 (2007)Cite this article

Anorexia nervosa (AN) is a serious disorder affecting adolescents and young adults, and decreases quality of life over long period.1 Successful weight restoration is an important prognostic factor for disease outcome;1 however, the underlying mechanism of refeeding-resistance (RR), a core psychopathology relevant to ‘ambivalent’ eating behaviors, remains unclear in this disorder.2, 3, 4

High mobility group box 1 (HMGB1), a ubiquitous DNA binding protein,5 plays various extracellular roles as a proinflammatory cytokine, an immune adjuvant, a repair factor for injured tissues and a mediator of anorexia.6, 7, 8 We therefore investigated whether serum HMGB1 levels are associated with acute conditions, refeeding progress or RR in patients with AN.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Steinhausen HC . Am J Psychiatry 2002; 159: 1284–1294.

    Article  Google Scholar 

  2. Yasuhara D, Naruo T, Nagai N, Muranaga T, Nakahara T, Tanaka M et al. Psychosom Med 2005; 67: 669–676.

    Article  Google Scholar 

  3. Yasuhara D, Naruo T, Nagai N, Tanaka M, Muranaga T, Nozoe S . Am J Clin Nutr 2003; 77: 292–299.

    Article  CAS  Google Scholar 

  4. Inui A . Mol Psychiatry 2001; 6: 620–624.

    Article  CAS  Google Scholar 

  5. Bustin M . Mol Cell Biol 1999; 19: 5237–5246.

    Article  CAS  Google Scholar 

  6. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J et al. Science 1999; 285: 248–251.

    Article  CAS  Google Scholar 

  7. Agnello D, Wang H, Yang H, Tracey KJ, Ghezzi P . Cytokine 2002; 18: 231–236.

    Article  CAS  Google Scholar 

  8. Yamada S, Maruyama I . Clin Chim Acta 2007; 375: 36–42.

    Article  CAS  Google Scholar 

  9. Yasuhara D, Nakahara T, Harada T, Inui A . Am J Psychiatry 2007; 164: 528–529.

    Article  Google Scholar 

  10. Corcos M, Guilbaud O, Paterniti S, Moussa M, Chambry J, Chaouat G et al. Psychoneuroendocrinology 2003; 28: 229–249.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Behavioral Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

    D Yasuhara, T Nakahara, T Harada, H Taguchi & A Inui

  2. Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

    T Hashiguchi, K Kawahara & I Maruyama

  3. Central Institute, Shino-Test Corporation, Sagamihara, Kanagawa, Japan

    S Yamada

Authors
  1. D Yasuhara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T Hashiguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K Kawahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Nakahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T Harada
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H Taguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. I Maruyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Inui
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D Yasuhara.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yasuhara, D., Hashiguchi, T., Kawahara, K. et al. High mobility group box 1 and refeeding-resistance in anorexia nervosa. Mol Psychiatry 12, 976–977 (2007). https://doi.org/10.1038/sj.mp.4002050

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4002050

This article is cited by

Search

Advanced search

Quick links